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ea0081p273 | Adrenal and Cardiovascular Endocrinology | ECE2022

Salivary profiles of cortisol and cortisone in patients with primary adrenal insufficiency under replacement therapy: a pilot study

Tucci Lorenzo , Vicennati Valentina , Magagnoli Matteo , Colombin Giacomo , Coscia Kimberly , Rotolo Laura , Fanelli Flaminia , Pagotto Uberto , Di Dalmazi Guido

Background: Evaluation of steroid replacement therapy (SRT) in adrenal insufficiency (AI) is challenging for the lack of reliable parameters. Measurement of salivary cortisol and cortisone emerged as a non-invasive tool for AI management, however poorly investigated. Aim: To analyse the cortisol and cortisone circadian rhythm in normal controls (NC) and patients with primary AI (PAI) under different SRTs, and to identify useful biomarkers. <p class="...

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ea0081oc2.4 | Oral Communications 2: Adrenal and Cardiovascular Endocrinology 1 | ECE2022

Autonomous cortisol secretion in adrenal incidentalomas and risk of fragility fractures: a large cross-sectional study

Zavatta Guido , Vicennati Valentina , Altieri Paola , Colombin Giacomo , Coscia Kimberly , Fanelli Flaminia , Malagrino1 Matteo , Magagnoli Matteo , Tucci Lorenzo , Pagotto Uberto , Di Dalmazi Guido

Context: Autonomous cortisol secretion (ACS) has been associated with a higher prevalence of osteoporosis and fragility fractures in several studies. However, the data rely on heterogeneous studies and criteria for osteoporosis screening in this population are still debated.Objective: To assess the prevalence of fragility fractures and contributing factors in a large cohort of patients with adrenal incidentalomas.Methods: We review...

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ea0081rc13.5 | Rapid Communications 13: Adrenal and Cardiovascular Endocrinology 2 | ECE2022

Skeletal muscle mass in patients with adrenal incidentaloma

Colombin Giacomo , Vara Giulio , Fanelli Flaminia , Magagnoli Matteo , Tucci Lorenzo , Coscia Kimberly , Mosconi Cristina , Pagotto Uberto , Vicennati Valentina , Di Dalmazi Guido

Background and aim: The relationship between sarcopenia and overt cortisol excess as in Cushings syndrome is well-known. However, only a few studies investigated the relationship between autonomous cortisol secretion (ACS) in adrenal incidentalomas and skeletal muscle mass. The aims of our study were to analyze the skeletal muscle mass in patients with adrenal incidentalomas and to investigate the correlations with hormonal data.Methods: We enrolle...

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ea0090p559 | Adrenal and Cardiovascular Endocrinology | ECE2023

Anxiety, depression, quality of life and sleep: new insights in adrenal insufficiency care through salivary cortisol and cortisone diurnal rhythm measurement

Tucci Lorenzo , Vicennati Valentina , Bissi Valentina , Galante Greta , Colombin Giacomo , Coscia Kimberly , Improta Ilaria , Rotolo Laura , Fanelli Flaminia , Pagotto Uberto , Di Dalmazi Guido

Background: Adrenal insufficiency patient (AIP) care is mostly based on symptoms or clinical signs of inadequate glucocorticoid replacement treatment (GRT). Salivary cortisol (F) and cortisone (E) recently emerged as new tools for AIP management, although poorly employed in clinical practice.Aim: To assess associations between salivary glucocorticoid measures and life quality, anxiety depressive symptoms, sleep quality in AIP.Metho...

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ea0093oc47 | Oral communication 7: Diabetes, Obesity and Metabolism | EYES2023

Amino acids and biogenic amines circadian fluctuation in health and in hypercortisolism states

Galante Greta , Tucci Lorenzo , Improta Ilaria , Bissi Valentina , Perrone Alessandro , Coscia Kimberly , Colombin Giacomo , Di Cintio Ilaria , Vicennati Valentina , Pagotto Uberto , Di Dalmazi Guido , Fanelli Flaminia

Background: Chronic hypercortisolism exhibits irregular circadian rhythm and deranged protein metabolism. Altered amino acid(AA) and biogenic amine(BA) circulating levels were found in patients with hypercortisolism. However, there is limited information about the physiologic circadian fluctuation of AA and BA levels, and it is not known whether this is affected by states of hypercortisolism.Aim: To characterize levels and daily fluctuations of AA and BA...